Oligonucleotide Synthesis Market Forecast 2025–2030: Growth Trends, Key Drivers & Future Outlook

 

Why Oligonucleotide Synthesis Matters in 2025

The global oligonucleotide synthesis market is entering a high-growth phase, fueled by advancements in genomics, therapeutics, and diagnostics. Valued at US$8.9 billion in 2024, the market reached US$10.5 billion in 2025 and is expected to skyrocket to US$24.7 billion by 2030, reflecting an impressive CAGR of 18.6%.

As precision medicine, genetic testing, and RNA-based therapeutics reshape modern healthcare, the demand for high-quality synthesized oligonucleotides is accelerating worldwide. This surge underscores their pivotal role in drug discovery, disease diagnosis, and personalized treatment pathways.

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Market Growth Insights & Trends

The oligonucleotide synthesis market is witnessing rapid expansion, supported by:

  • Strong CAGR (2025–2030): 18.6%
  • Forecasted valuation by 2030: US$24.7 billion
  • Key industries adopting oligonucleotides: pharmaceuticals, biotechnology, diagnostics, and academic research

Trending applications include:

  • Gene editing technologies (CRISPR-Cas9)
  • RNA-based drugs (mRNA vaccines, antisense therapies, siRNA therapies)
  • Companion diagnostics and biomarker discovery
  • Synthetic biology & molecular diagnostics

Key Drivers of Market Growth

  1. Rising Demand for RNA Therapeutics
    • mRNA vaccines and RNA interference (RNAi) therapies are expanding the role of oligonucleotides in healthcare.
  2. Advancements in Genomic Research
    • Growing adoption of next-generation sequencing (NGS) and synthetic biology is creating a higher need for custom oligonucleotide synthesis.
  3. Personalized & Precision Medicine
    • Tailored therapeutics and diagnostics depend on accurate oligonucleotide sequences, boosting demand.
  4. Biotech & Pharma Industry Expansion
    • Increased investments in biotech R&D and drug pipelines are fueling large-scale oligonucleotide production.

Challenges & Opportunities

Challenges:

  • High cost of synthesis technologies
  • Complex regulatory landscape for nucleic acid-based drugs
  • Quality control and scalability issues in manufacturing

Opportunities:

  • Growth in custom oligonucleotide services for research labs and biotech startups
  • Expansion of therapeutic oligonucleotides in oncology and rare diseases
  • Integration of AI & automation in oligonucleotide synthesis to reduce costs and enhance efficiency

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Competitive Landscape: Key Players

The oligonucleotide synthesis market is highly competitive, with major companies investing heavily in R&D and advanced manufacturing platforms. Leading players include:

  • Agilent Technologies
  • Thermo Fisher Scientific
  • Integrated DNA Technologies (IDT)
  • Merck KGaA
  • Eurofins Genomics
  • Twist Bioscience
  • Bio-Synthesis Inc.

Future Outlook: Oligonucleotide Synthesis Market by 2030

Looking ahead, the future of the oligonucleotide synthesis industry will be shaped by:

  • Wider adoption of RNA-based drugs beyond COVID-19 vaccines
  • Innovations in synthetic biology enabling advanced therapeutic platforms
  • Increased clinical validation of antisense and siRNA therapies
  • Partnerships between pharma, biotech, and contract manufacturers to scale production

By 2030, oligonucleotides are expected to play a mainstream role in personalized medicine, reshaping drug pipelines and diagnostic strategies globally.

Conclusion & Call-to-Action

The oligonucleotide synthesis market is on track to nearly triple in value by 2030, making it one of the most dynamic segments in biotechnology. With applications spanning therapeutics, diagnostics, and genomics, this sector represents a prime opportunity for investors, biotech firms, and healthcare innovators.

🚀 Businesses that invest in advanced oligonucleotide synthesis today will lead the future of precision medicine tomorrow.

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FAQs

1. What is driving growth in the oligonucleotide synthesis market?
The market is driven by the rising use of oligonucleotides in RNA-based drugs, diagnostics, and personalized medicine.

2. How big will the oligonucleotide synthesis market be by 2030?
It is projected to reach US$24.7 billion by 2030, growing at a CAGR of 18.6%.

3. Which companies are leading in oligonucleotide synthesis?
Key players include Thermo Fisher Scientific, Agilent Technologies, Integrated DNA Technologies, Merck KGaA, and Twist Bioscience.

4. What are the challenges in oligonucleotide synthesis?
Challenges include high production costs, regulatory complexity, and scalability issues.

5. How are oligonucleotides used in therapeutics?
They are applied in mRNA vaccines, antisense therapies, siRNA treatments, and precision medicine

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